Endocrine Abstracts

Introduction: Acromegaly is known to be associated with obstructive sleep apnea syndrome (OSAS) in about 60–70% of the cases. Both OSAS and acromegaly are thought to be responsible from cardiovascular diseases and endothelial dysfunction. The aim of the present study was to investigate the role of OSAS on cardiovascular effects of acromegaly.Materials and Methods: 25 patients with acromegaly and 7 healthy volunteers were enrolled into the study. Car...

Objective: To report a rare cause of ectopic adrenocorticotropic hormone (ACTH) secretion leading to Cushing syndrome.Methods: We describe the clinical presentation and management of a case of Cushing syndrome attributable to ectopic ACTH secretion from small cell cancer of the prostate.Results: In a 74-year-old man developed hypocalemia and heart failure. He was found to have severe hypokalemia (serum potassium, 2.37 mEq/l). Hormo...

Background: Plasma carnitine insufficiency has been caused muscle weakness. Carnitine levels and pulmonary functions were lower in patients with diabetes.Objective: To determine whether pulmonary functions are correlated with carnitine levels in patients with type 2 diabetes.Setting: Internal medicine outpatient clinic of a university hospital.Methods: Forty-nine patients with type 2 diabetes and 34 healthy c...

Objective: Higher obesity rates are related with increased non-alcoholic fatty liver disease (NAFLD) prevalence which may progress further to non-alcoholic steatohepatitis (NASH) and cirrhosis. The utility of Fibroscan was shown in stratifying risk for significant liver disease. The aim of the study was to evaluate the relation between body mass index (BMI) and liver stiffness measurements (LSM) in overweight and obese patients.Methods: We conducted the ...

The co-occurrence of congenital adrenal hyperplasia and type 1 diabetes mellitus (T1DM) is a rare phenomenon in existing literature. The primary cause of congenital adrenal hyperplasia (CAH) is often 21-hydroxylase deficiency (21OHD), a condition associated with the CYP21A2 gene located on chromosome 6p21.3 within the major human leukocyte antigen (HLA) histocompatibility locus. Various gene polymorphisms, particularly in HLA-DQalpha, DQbeta, and DR genes on chromosome 6p21.32...

Introduction: Ectopic neurohypophysis is a congenital abnormality related to faulty embryogenesis resulting in incomplete caudal extension of the infundibulum. It may present itself with symptoms of growth hormone deficiency or panhypopituitarism and patients require replacement treatment for panhypopituitarism.Case Presentation: Our female patient was shorter (138 cm) than her peers and did not menstruate at the age of 19 when she first...

Background: The growth hormone (GH)/insulin-like growth factor-1 (IGF-1) axis has effects on renal growth and electrolyte regulation. However, data on adverse renal comorbidities such as renal cysts and stones in acromegaly is scarce. The current study aimed to investigate the prevalence of radiologically detectable renal comorbidities and possible related factors in the acromegaly population.Methods: A total of 125 patients with acromegaly (46.4±11.6...

Introduction: Recently, Programmed cell death ligand 1 (PD-L1) inhibitors have been frequently used as promising treatment options for some advanced malignancies. Although immune-related side effects secondary to PD-1 inhibitor treatment are well defined in the literature, data on PD-L1 inhibitors are limited. Thyroid dysfunction was reported in 10% of patients in the clinical study of atezolizumab. We aimed to present a case of severe hypothyroidism-related rhabdomyolysis and...

Introduction: Multiple endocrine neoplasia type 1 (MEN1) is a rare, heritable syndrome characterized by a hyperparathyroidism, pituitary adenoma and pancreatic islet cells.Case: A 56-year-old male patient had a single parathyroid excised for primary hyperparathyroidism 10 years ago. He was further investigated due to hypoglycemia and a mass was found in the head of the pancreas on MRI. It was reported as neuroendocrine tumor and no recurrence was found i...

Introduction: Langerhans cell histiocytosis (LCH) is a neoplastic histiocytic disorder that characterized by proliferation of abnormal Langerhans cells. The most typical organs affected by LCH are the skin and bones, though it can also affect the pituitary gland, central nervous system, liver, spleen, lungs, and other organs.Case 1: 36 year old man presented with polyuria, polydipsia and right hip pain lasting about 4 months. The pain increased in the la...